Quantitative tracking of T cell clones after haematopoietic stem cell transplantation
نویسندگان
چکیده
منابع مشابه
Quantitative tracking of T cell clones after haematopoietic stem cell transplantation
Autologous haematopoietic stem cell transplantation is highly efficient for the treatment of systemic autoimmune diseases, but its consequences for the immune system remain poorly understood. Here, we describe an optimized RNA-based technology for unbiased amplification of T cell receptor beta-chain libraries and use it to perform the first detailed, quantitative tracking of T cell clones durin...
متن کاملQuantitative tracking of T cell clones after hematopoietic stem cell transplantation
In particular, reviewer #2 feels that the study would be strengthened by the separation of CD4+ and CD8+ T cells in the analysis. Importantly, reviewer #1 feels that the potentially valuable software should be publicly available. Of note, both reviewers #1 and #2 feel that specific statements regarding the long-term reconstitution of the T cell repertoire or the treatment regimen, respectively,...
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Background Stem cell transplantation has become as a novel treatment for end-stage kidney, lung, heart , liver diseases and several hematologic disorders. Improved survival of transplant recipients has raised awareness of post-transplant complications. One of these complications is transplant-related osteoporosis. Methods In this manuscript we review prevention methods for transplant-relat...
متن کاملAcute phase after haematopoietic stem cell transplantation
The transplantation of allogeneic or autologous haematopoietic stem cells is an established treatment for many malignant and non-malignant diseases of the bone marrow. Intensive cytoreductive regimens administered before transplantation induce prolonged and severe cytopenia of all haematopoietic lineages. Thrombocytopenia leads to an increased risk of bleeding, which may be further aggravated b...
متن کاملDry eye after haematopoietic stem cell transplantation.
AIMS To determine the incidence, natural course, and severity of dry eye occurring or worsening after haematopoietic stem cell transplantation (SCT). METHODS At a tertiary care hospital, 53 patients undergoing allogeneic or autologous SCT followed by at least 180 days of follow up were studied prospectively. Examination included grading of symptoms of dry eye, evaluation of ocular surface, te...
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ژورنال
عنوان ژورنال: EMBO Molecular Medicine
سال: 2011
ISSN: 1757-4676,1757-4684
DOI: 10.1002/emmm.201100129